In 1928, a fortunate stroke of serendipity by Alexander Fleming led to the invention of the first antibiotic - penicillin. This wonder drug had the ability to kill bacteria and completely revolutionized medicine by significantly reducing mortality due to infections. Since then, modern medicine has made several advancements and newer classes of antibiotics such as Cephalosporins, Fluoroquinolones and Carbapenems have been developed. These constitute of both first-line antibiotics like Penicillin and last-resort antibiotics like Carbapenems.
Antimicrobial Resistance (AMR) can be defined as resistance of a microorganism to an antimicrobial medicine to which it was previously sensitive. AMR is survival of the fittest based on Darwin Theory where microbes adopt various mechanisms to shield themselves from antimicrobial drugs and survive.
Antibiotic resistance refersto ability of the bacteria to render an antibiotic drug ineffective by developing mechanisms that counteract the functioning of antibiotic drugs. In other words, the antibiotic can no longer kill the bacteria and bacterial growth is not stopped.
This has severe life threatening implications as common infections like pneumonia that were otherwise treatable can now become fatal. Moreover, it challenges all the advances that we have made in modern medicine, making child birth and surgeries a much riskier proposition.
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