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Bacteria adopt all possible ways to survive when exposed to drugs.
Ways of Acquiring Resistance
Bacteria adopt all possible ways to survive when exposed to drugs.
Ways of Acquiring Resistance
Ways of Acquiring
Resistance
Bacteria adopt all possible ways to survive when exposed to
drugs. Depending upon type of bacteria (gram positive/ gram
negative) the approaches vary. The most common of these in general
include:
Not permitting drug to enter
Either by closing
porin channels
My making alteration
in outer membrane proteins to reduce permemability
By secreting
extracellular enzymes to deactivate the drug
By secreting intracellular enzymes for deactivation of drug
Extended spectrum
beta lactamases secretion
Aminoglycoside
modifying enzyme secretion
Efflux the drug out of bacterial cell
By making biofilms formation (when single bacteria or a small
population is under threat they colonize and form protective layer
around them, called biofilm)
By altering the binding sites of drug
By transferring resistant genetic material to
neighboring non-resistant microbes
Ways of Acquiring Resistance